Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4625-8. doi: 10.1016/j.bmcl.2012.05.051. Epub 2012 May 18.

Abstract

A methanol extract of the twigs of Cinnamomum cassia was found to inhibit xanthine oxidase. Purification of the methanol extract afforded three new phenolic glycosides, cinnacasolide A-C (11-13), together with 10 known compounds (1-10). The structures of the three new compounds were determined by interpretation of spectroscopic data. Cinnamaldehyde derivatives 1-5 and 7 were significant inhibitors of xanthine oxidase, with IC(50) values ranging from 7.8 to 36.3 μg/mL. The results indicate that the acyl group of these cinnamaldehyde derivatives plays an important role in the inhibition of xanthine oxidase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cinnamomum aromaticum / chemistry*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology
  • Molecular Structure
  • Structure-Activity Relationship
  • Xanthine Oxidase / antagonists & inhibitors*

Substances

  • Enzyme Inhibitors
  • Xanthine Oxidase